Sjögren-Like Lacrimal Keratoconjunctivitis in Germ-Free Mice

Sjögren-Like Lacrimal Keratoconjunctivitis in Germ-Free Mice

Commensal bacteria play an important role in the formation of the immune system but their role in the maintenance of immune homeostasis at the ocular surface and lacrimal gland remains poorly understood. This study investigated the eye and lacrimal gland phenotype in germ-free and conventional C57BL/6J mice. Our results showed that germ-free mice had significantly greater corneal barrier disrup...

Bilateral Lacrimal Gland Lymphoma in Sjögren Syndrome

A 31-year-old female with Primary Sjögren Syndrome (pSS) presented with bilateral puffiness around the eye for 3 years. The lacrimal glands were hypertrophic and edematous bilaterally. Schirmer 1 score was 2 and 1 mm and tear-film break-up time was 3 and 4 seconds, in the right and the left eyes, respectively. An incisional biopsy from the left lacrimal gland revealed diffuse and intense CD20, ...

Histology of the lacrimal gland in keratoconjunctivitis sicca.

Lymphoid Cells of Germ-free Mice

Previous studies of enzymatically iodinated splenocytes from normal BALB/c mice indicate that cell surface Ig is primarily 8S IgM (1) which is rapidly released on a fragment of plasma membrane (shedding) during incubation of iodinated cells (2). In contrast, labeling of the same cell population with [SH]tyrosine results in secretion of radioactive IgG, 19S IgM, and 8S IgM all unassociated with ...

Establishment of Human Indigenous Bacteria in Germ-free Mice.

Gibbons, R. J. (Forsyth Dental Center and Harvard School of Dental Medicine, Boston, Mass.), S. S. Socransky, and B. Kapsimalis. Establishment of human indigenous bacteria in germ-free mice. J. Bacteriol. 88:1316-1323. 1964.-Thirteen strains of bacteria indigenous to the gingival crevice area of man were tested for their ability to establish as monocontaminants in germ-free mice. Three facultat...